conditions

Major Depressive Disorder

Depression that hasn't lifted after several medications is common, and it is not the end of the road. At VieClinic, we offer TMS, which helped 58% of people who had already tried an average of 2.5 antidepressants, with sessions as short as 3 minutes.

Major Depressive Disorder (MDD) or depression is a common mental health condition that affects how a person feels, thinks, and behaves. It goes beyond temporary feelings of sadness or low mood—depression can cause persistent emotional and physical symptoms that interfere with daily life. It’s one of the most common causes of disability worldwide.

+ benefits

Trusting in Vieclinic

Results in Real Clinics

Across 42 clinics, 58% of adults who had already tried an average of 2.5 antidepressants responded to TMS, and 37% reached remission.

Results That Last

Of the people who improved with TMS, 62.5% still met response criteria a year later, with booster sessions available if symptoms return.

When Another Medication Switch Isn't Working

In adults who had not improved after two treatments, 37.5% responded to TMS, compared with 14.6% of those who switched medication.

+ Other Treatments

Pharmacotherapy

Treatment options can help manage symptoms and improve quality of life.

SSRIs (Selective Serotonin Reuptake Inhibitors)


First-line treatments due to their effectiveness and relatively mild side effects. They increase serotonin levels to help regulate mood. Common side effects include sleep disturbances, gastrointestinal upset, and sexual dysfunction.

Examples: fluoxetine, sertraline, citalopram

TCAs (Tricyclic Antidepressants)

Used for more severe depression when SSRIs are ineffective. Though effective, they are often limited by side effects like sedation, weight gain, and anticholinergic symptoms.


Examples: amitriptyline, nortriptyline, imipramine.

MAOIs (Monoamine Oxidase Inhibitors)


Reserved for treatment-resistant cases due to significant dietary restrictions and potential drug interactions.

Examples: phenelzine, tranylcypromine.

SNRIs (Serotonin-Norepinephrine Reuptake Inhibitors)

Often prescribed when SSRIs are not effective. By increasing both serotonin and norepinephrine, they may be especially beneficial for those with fatigue or chronic pain.


Examples: venlafaxine, duloxetine

Ketamine/Esketamine


Emerging treatments for treatment-resistant depression and acute suicidal ideation. Administered under supervision, promising but still under long-term study. Examples: IV ketamine, intranasal esketamine (Spravato)

Psychotherapy

Cognitive-Behavioral Therapy (CBT)

Identifies and changes negative thoughts and behaviours.

Mindfulness-Based Therapy

Promotes awareness and acceptance of thoughts.

Behavioral Activation

Increases engagement in rewarding activities.

Interpersonal Therapy (IPT)

Improves relationships and social functioning.

Problem-Solving Therapy

Helps manage daily challenges.

+ RESEARCH

Data Saves Lives especially when it comes to the brain.

Consensus Recommendations for the Clinical Application of Repetitive Transcranial Magnetic Stimulation (rTMS) in the Treatment of Depression - PMC

Regulatory Clearance and Approval of Therapeutic Protocols of Transcranial Magnetic Stimulation for Psychiatric Disorders - PMC

Recovering from depression with repetitive transcranial magnetic stimulation (rTMS): a systematic review and meta-analysis of preclinical studies - PMC

Effectiveness and acceptability of accelerated repetitive transcranial magnetic stimulation (rTMS) for treatment-resistant major depressive disorder: An open label trial - ScienceDirect

Accelerated TMS for Depression: A Systematic Review and Meta-Analysis - PMC

Response trajectory to left dorsolateral prefrontal rTMS in major depressive disorder: A systematic review and meta-analysis: Trajectory of rTMS - ScienceDirect

Neuroinflammation mechanisms of neuromodulation therapies for anxiety and depression - PMC

Evidence-based guidelines on the therapeutic use of transcranial direct current stimulation (tDCS) - ScienceDirect

Transcranial direct current stimulation (tDCS) in depression induces structural plasticity - PMC

Effect of add-on transcranial alternating current stimulation (tACS) in major depressive disorder: A randomized controlled trial - Brain Stimulation: Basic, Translational, and Clinical Research in Neuromodulation

Application of Transcranial Direct and Alternating Current Stimulation (tDCS and tACS) on Major Depressive Disorder - PubMed

Photobiomodulation: shining a light on depression - PMC

Photobiomodulation improves depression symptoms: a systematic review and meta-analysis of randomized controlled trials - PMC

+ symptoms

Posible symptoms

To be diagnosed with MDD, a person needs to have at least five of the following symptoms for at least two weeks:

  1. Feeling sad or hopeless most of the day, nearly every day.
  2. No longer enjoying things that used to be fun or interesting.
  3. Feeling worthless or guilty in an excessive way.
  4. Low energy or tiredness, even after rest.
  5. Difficulty concentrating or making decisions.
  6. Changes in appetite or weight, either eating too much or too little.
  7. Sleep problems,  either sleeping too much or struggling to sleep.
  8. Feeling restless or slowed down in body or thoughts.
  9. Thoughts of death or suicide.

If you or someone you know is experiencing these symptoms, it’s crucial to seek help. Depression can be treated with therapy, medication, or a combination of both.

+ Transform Your life

Start with a Free Consultation

Every breakthrough begins with understanding. 

During your consultation, we listen to your story, review your health goals, and map out a non-invasive care pathway engineered specifically for your brain.

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